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KMID : 0617919850030010001
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Wonkwang Oriental Medicine
1985 Volume.3 No. 1 p.1 ~ p.32
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Effect of Panax Ginseng on the Contractile Force Intrauterine Pressure and Spontaneous Activity of the Isolated Rat Uterus
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Abstract
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Ginseng has been employed for a large variety of disorders as a panaceal therapeutic drug as well as a tonic remedy in oriental medicine for centuries. But its mysterious effect are not yet fully elucidated. However, as a results of numerous investigations, panax saponin, and etherial and non-etherial components have been isolated from ginseng, and a wide range of their pharmacological properties has been ascribed. Among those studies on ginseng, many investigators have observed that ginseng extract causes a marked contraction of intestinal or uterine strip, and have ascribed it to the release or endogenous histamine or 5-hydroxytryptamine.
This investigation was carried out to see the effect if ginseng ethanol extract on the contractile force, intrauterine pressure, and spontaneous activity of isolated rat uteris, and to elucidate its mechanism. Ginseng elicited concentration-dependant increas of contractile force, intrauterine pressure and spontaneous activity of nonpregnant and pregnant rat uterus. Ginseng (1 or 100mg/㎖) caused a parallel shift of the dose response curve of acetylcholine, histamine or 5-hydroxytrytamine : But ginseng did not change the dose respone curve of oxytocin. Ginseng potentiated the acetylcholine, histamine or 5-hydroxtryptamine induced increase of contractile force, intrauterine pressure and spontaneous activity of the rat uterus, but did not effect the action of oxytocin in the preparation. Atropine (10 ug/㎖) did not inhibit the action of ginseng, bit phenyramine (10 ug/㎖) or cyproheptadine (0.5 ug/㎖) partially blocked the action of ginseng. Change of electrolyte concentration in the medium affects the contractile force of, intrauterine pressure and spontaneous activity of the preparation. However, decrease of Na ion, or increase of K ion or Ca ion in the medium diminished the action of ginseng, while increase of Mg ion or addition of Mn ion into the medium scarcely affect the action of ginseng.
Thus, it is sugested that effect of gindeng ethanol extract on the contractile force, intrauterine pressure and spontaneous activity of the rat uterus is partly due to release of endogenous substances such as histamine and 5-hydroxytryptamine, and partly due to direct related to muscle contraction is conceivably comprised.
It is obtained that as results of those above experiments, Panax Ginseng seems to be effective in preventing and treatmenting for gynecological diseases which is corelated with of uterine contractile force, intra-uterine pressure and spontaneous activity.
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